- We use the cutting-edge method of massively parallel sequencing and, from whole-exome data (WES), evaluate the virtual CZECANCA panel. This panel covers 259 genes associated with hereditary cancers. More information is available on the GNTlabs website.
- The data obtained are analysed by means of bioinformatic evaluation. The clinical interpretation of the variants found is performed by qualified specialists on the basis of the indication for testing, current scientific literature, and international databases. Each of the above steps is accompanied by quality control.
Oncogenetics
Cancer is common in the population, yet only 10 to 15 % of cases (up to 20 % in children) arise on the basis of an inherited predisposition. It is this group of cancers that genetic testing focuses on.
The aim of genetic testing is to determine whether the family case represents an inherited predisposition, to clarify the risk of developing cancer and the type of disease, and to recommend appropriate prevention.
Why Entrust Oncogenetic Testing to Gennet?
Who Should Consider Genetic Testing?
Genetic testing may be appropriate for people in whom a hereditary cancer predisposition is suspected. Please pay particular attention in the following situations:
- Carcinoma of the pancreas, ovary, fallopian tube, or peritoneum at any age
- Any other cancer occurring before the age of 50
- Several different types of cancer in a single patient
- A tumour in both paired organs (for example in both breasts or both kidneys).
- A tumour in an atypical location or of a rare histological type
- Recurring cancer in the family, especially of the same type (for example grandmother, mother, and sister all having breast cancer)
- A combination of specific cancer types in the family (for example breast and ovary, colon and uterus).
Not sure?
If you are not sure whether oncogenetic testing is appropriate for you, please feel free to ask your treating physician (you can download an indication card for them) or our clinical geneticists directly.
How Does an Oncogenetic Consultation and Testing Work?
Consultation with a clinical geneticist
Indication for genetic testing
Sample collection and analysis
Final consultation and results
Your personal prevention plan
Consultation with a clinical geneticist
Everything begins with a detailed conversation about your personal and family medical history. Together we draw up a three-generation pedigree and assess whether a hereditary cancer syndrome is suspected in your case. Information about the type of cancer, the age at diagnosis, and the histology result is essential.
Indication for genetic testing
Based on this information, the doctor will assess whether genetic testing focused on predisposition genes is suitable for you or one of your relatives.
Where possible, testing usually begins with a family member who currently has, or has previously had, cancer.
Sample collection and analysis
The testing itself is performed using a simple blood sample or, in some cases, a buccal swab from the lining of the mouth.
Final consultation and results
Once the results are available, usually within a few weeks, the geneticist will explain them to you clearly and in detail during the final consultation.
They will also clarify any potential risks and recommend appropriate prevention and monitoring for you and your relatives, including genetic testing where relevant.
Your personal prevention plan
What Happens After You Receive the Results?
A test result is not just information. It serves as the basis for specific next steps. Based on the findings, we may recommend:
A Personalised Screening Plan
An adjusted preventive care plan, such as more frequent mammograms or colonoscopies at a younger age.
Preventive Measures
This may include enrolment in specialised monitoring programmes from a younger age to support early detection of a potential cancer diagnosis.
In some cases, preventive surgery may be recommended to reduce the risk of the disease developing.
Targeted Biological Treatment
For oncology patients, knowing the specific genetic mutation may help doctors select the most effective type of treatment.
Protecting Future Generations
If you are planning a family, we offer Preimplantation Genetic Testing for Monogenic Disorders, PGT-M. As part of an IVF cycle, this makes it possible to select embryos that have not inherited the risk mutation, helping to eliminate the transmission of the predisposition to the next generation.
Cost and Insurance Coverage
Is It Covered by Health Insurance?
Yes, when the indication criteria are met
A genetic consultation recommended by your treating physician is covered by health insurance. If, in the assessment of the clinical geneticist, the indication criteria for oncogenetic testing of predisposition genes are met, this genetic examination is also fully covered. If the indication is not met, the genetic examination can be offered as a self-pay service; we will inform you in advance about the price and payment options.
Frequently Asked Questions (FAQs)
Do you have questions that only a geneticist can answer? Take the first step. Our team at the Gennet Centres for Medical Genetics in Prague and Liberec is here for you.
What if the test shows a hereditary predisposition?
A genetic predisposition doesn’t guarantee that a disease will develop. However, it allows for preventive steps, regular monitoring, or lifestyle adjustments that can reduce your risk.
Can genetic testing help with treatment?
Yes, in some cases, genetic test results significantly influence the treatment options available to cancer patients.
How long does it take to get the results?
Urgent testing required before surgery or for treatment planning can be done within 2–3 weeks. Typically, results are available within 8 weeks. We will inform you about the expected timeline in advance.
Will my relatives be affected by the result?
If a hereditary cancer predisposition is confirmed, your relatives will be offered a predictive test (to check whether they also carry the same mutation). The result helps clarify their cancer risk and ensures timely preventive care. Predictive testing is usually done in adulthood, though in some cases, testing children is appropriate — depending on the expected age of disease onset.
Why to use the ONCOPANEL for testing?
The panel allows for the simultaneous testing of many genes in one lab test. Mutations in different genes can lead to the same type of cancer, and the same cancer can arise from mutations in various genes. This method is faster and more cost-effective than testing individual genes separately. All identified mutations are confirmed by traditional sequencing from a second independent DNA sample.
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A genetic consultation will help you better understand your health situation, family history, and possible hereditary factors. Our specialists will provide expert advice and recommendations for next steps.
