Pharmacogenetic Testing (PGX)

Personalized Medicine Based on Your DNA

Pharmacogenetics examines how your genes affect the way your body responds to medications. By identifying genetic variants that influence drug metabolism, this test helps doctors choose the most effective medication and dosage—minimizing side effects and improving treatment success.

This is a key tool in personalized medicine, especially for patients undergoing long-term therapy or taking multiple medications.

Why Pharmacogenetic Testing?

Avoids “trial and error” prescribing
Reduces the risk of adverse drug reactions
Improves treatment outcomes and safety
Provides lifelong insight—your DNA doesn’t change
Supports decisions in cardiology, psychiatry, oncology, and other fields

Who Should Consider PGX Testing?

Patients starting new long-term medication (e.g. antidepressants, statins, pain relievers)
Individuals who experienced side effects or poor response to medications
People taking multiple drugs at once (polypharmacy)
Patients with chronic conditions (e.g. heart disease, mental health disorders)
Couples planning IVF with known medication sensitivities

What Is Analyzed?

The PGX panel includes key genes involved in drug metabolism:

CYP2D6, CYP2C19, CYP3A5, and others
Genetic markers affecting drug transport and receptor sensitivity
Variants linked to serious drug reactions (e.g. HLA alleles)

Interpretation is based on international guidelines (e.g. CPIC, PharmGKB).

What Will You Receive?

Your metabolizer status: Poor, Intermediate, Normal, Rapid, or Ultra-Rapid
A report with drug-specific recommendations
Guidance for your physician on dose adjustments or alternative medications

Examples of Drugs Affected by Genetics

Antidepressants and psychiatric medications
Painkillers (codeine, tramadol)
Blood thinners (clopidogrel, warfarin)
Cholesterol-lowering drugs (statins)
Proton pump inhibitors (omeprazole)
Cancer therapies, antivirals, and antibiotics

How Is the Test Performed?

A simple blood draw or buccal (cheek) swab
Testing is done in our own GNTlabs by GENNET
Results are interpreted by clinical geneticists and tailored to your needs

Specialised Laboratory: GNTlabs by Gennet

GNTlabs by GENNET is one of the leading genetic laboratories in Central Europe and continues the work of the Gennet clinics, dating back to 1996.

We specialise in reproductive genetics — preconception, preimplantation, and prenatal — as well as postnatal genetics. We work with clinical centres across Europe and provide molecular genetic diagnostics at a high professional standard.

Close cooperation with the clinics and their patients allows us to apply innovative methods not only in specialised cases, but also in the routine diagnostic work on every sample.

More About GNTlabs

Frequently Asked Questions (FAQs)

How long does it take to get results?

Additional genetic tests

Turnaround times vary depending on the test. We will always inform you of the expected timeline upon ordering.

How much do genetic tests cost?

Additional genetic tests

In medically indicated cases, testing may be covered by health insurance. For self-paid options, prices vary based on the type and scope of the test.

Do I need a referral from a doctor?

Additional genetic tests

For most tests, a referral from your physician to a genetic consultation is recommended. The clinical geneticist will then determine the appropriate indication. Some tests, such as thrombophilia mutations, may be referred directly by your gynecologist. For self-pay tests like paternity testing, no referral is needed.

Schedule an appointment for a genetic consultation.

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A genetic consultation will help you better understand your health situation, family history, and possible hereditary factors. Our specialists will provide expert advice and recommendations for next steps.