A new laboratory method increasing the chance of getting pregnant



The ZONA FREE method is a special type of assisted fertilisation and implantation where the embryo is completely stripped of the outer layer (Zona pellucida – ZP). The method is recommended for clients in whom antibodies against ZP – AZP proteins have been shown.
AZP is an immunopathology that contributes to fertility disorders. Before treatment with IVF, although immunologists try to suppress the production of AZP with drugs that weaken the immune response, the treatment is not always successful enough to make the antibodies completely disappear from the circulation.
Even if the blood test for AZP shows negative, its presence can never be ruled out below the detection limit, which can still harm the embryo. However, an embryo deprived of ZP protein residues is "uninteresting" to AZP, and once it is inserted into the uterus, AZP can no longer harm it. 

After removal of the embryo outer layer using the ZONA FREE method, in 2019 65% of patients with proven AZP became pregnant

Who is the treatment for:

  • Patients who have been shown to have ZP antibodies.
  • Other cases, according to the physician's recommendation.

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Dear clients, we are the only assisted reproduction  centre in the Czech Republic that has at its disposal a revolutionary incubator with time-lapse imaging Embryoscope +  equipped with IDAScore software.


Dear clients, our clinic is in full operation and we would like to assure you that the government restrictions in the Czech Republic, don't have any impact on the treatment.    


We thank very much to our dear patient from Ireland who agreed to give us an interview about the whole process of IVF treatment, planning the stay in Prague and coming to our clinic. We are happy for her kind words, for choosing our clinic and giving us an opportunity to help her on her way to become mother.


Dear clients,   We would like to assure you that the latest changes concerning the government restrictions in the Czech Republic, don't have any impact on the treatment.  Our clinics remain open and we are in full operation without any restrictions.